Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads

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Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads

ATP-sensitive potassium (KATP) channels have the unique ability to adjust membrane excitability and functions in accordance with the metabolic status of the cell. Skeletal muscles are primary sites of activity-related energy consumption and have KATP channels expressed in very high density. Previously, we demonstrated that transgenic mice with skeletal muscle-specific disruption of KATP channel...

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Several lines of evidence suggest that ATP-sensitive potassium (KATP) channels are involved in glucose uptake by insulin target tissues. The aim of the present study was to prove directly the effect of KATP channel activity on glucose transport into cultured human skeletal muscle cells. We used potassium channel openers PCO400 and nicorandil alone or in combination with channel blockers glibenc...

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Localization and function of ATP-sensitive potassium channels in human skeletal muscle.

The present study investigated the localization of ATP-sensitive K+ (KATP) channels in human skeletal muscle and the functional importance of these channels for human muscle K+ distribution at rest and during muscle activity. Membrane fractionation based on the giant vesicle technique or the sucrose-gradient technique in combination with Western blotting demonstrated that the KATP channels are ...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 2013

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.201311063